Pharmacology articles from across Nature Portfolio

Pharmacology is a branch of biomedical science, encompassing clinical pharmacology, that is concerned with the effects of drugs/pharmaceuticals and other xenobiotics on living systems, as well as their development and chemical properties.

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Latest Research and Reviews

Epigenetic mechanisms of rapid-acting antidepressants

Reviews Open Access 04 Sept 2024 Translational Psychiatry Volume: 14, P: 359

Pharmacological and non-pharmacological predictors of the LSD experience in healthy participants

Research Open Access 04 Sept 2024 Translational Psychiatry Volume: 14, P: 357

GLP-1 receptor agonist exenatide uncouples food intake from hedonic and anticipatory regulation in non-human primates: insights from an operant meal schedule paradigm

Research Open Access 04 Sept 2024 Neuropsychopharmacology

Towards clinically relevant dose ratios for Cabamiquine and Pyronaridine combination using P. falciparum field isolate data

Here the authors use drug susceptibility data from Plasmodium falciparum field isolates in a pharmacometric model to evaluate cabamiquine and pyronaridine efficacy, both individually and in combination. The combined treatment shows over 90% parasite reduction in most simulated cases, providing valuable guidance for clinical dose selection in real-world settings.

Research Open Access 03 Sept 2024 Nature Communications Volume: 15, P: 7659

Structural basis for CCR6 modulation by allosteric antagonists

Small molecule antagonists of CCR6 are potential drugs for autoimmune disorders. Here the authors present inactive structures of CCR6 bound by different allosteric antagonists from two series simultaneously, offering multiple approaches to inhibit CCR6.

Research Open Access 31 Aug 2024 Nature Communications Volume: 15, P: 7574

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis